Rodolphe Barrangou , Viruses in Prokaryotes CRISPR Provides Acquired
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www.sciencemag.org (this information is current as of April 13, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/315/5819/1709 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/315/5819/1709/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/315/5819/1709#related-content http://www.sciencemag.org/cgi/content/full/315/5819/1709#otherarticles , 9 of which can be accessed for free: cites 20 articles This article http://www.sciencemag.org/cgi/collection/microbio Microbiology : subject collections This article appears in the following http://www.sciencemag.org/about/permissions.dtl in whole or in part can be found at: this article permission to reproduce of this article or about obtaining reprints Information about obtaining
منابع مشابه
QnAs with Rodolphe Barrangou.
The past decade in biological research might well be christened the age of CRISPR, a once-curious feature of bacterial genomes that spawned a handy tool for editing genes. Using CRISPR-based tools, researchers are making leaps in basic clinical research, and biotechnology companies are racing to launch trials of gene therapies for an array of diseases. Yet the immediate gains from this game-cha...
متن کاملViruses in Prokaryotes CRISPR Provides Acquired Resistance
http://www.sciencemag.org/cgi/content/full/315/5819/1709 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/315/5819/1709/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...
متن کاملDiversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus.
Clustered regularly interspaced short palindromic repeats (CRISPR) are hypervariable loci widely distributed in prokaryotes that provide acquired immunity against foreign genetic elements. Here, we characterize a novel Streptococcus thermophilus locus, CRISPR3, and experimentally demonstrate its ability to integrate novel spacers in response to bacteriophage. Also, we analyze CRISPR diversity a...
متن کاملCRISPR Acquired Resistance Against Viruses (2007)
In 2007, Philippe Horvath and his colleagues explained how bacteria protect themselves against viruses at Danisco, a Danish food company, in Dangé-Saint-Romain, France. Horvath and his team worked to improve the lifespan of bacteria cultures for manufacturing yogurt and ice cream. Specifically, they focused on bacteria?s resistance to bacteriophages, or viruses that infect bacteria. Horvath and...
متن کاملCRISPR/Cas, the immune system of bacteria and archaea.
Microbes rely on diverse defense mechanisms that allow them to withstand viral predation and exposure to invading nucleic acid. In many Bacteria and most Archaea, clustered regularly interspaced short palindromic repeats (CRISPR) form peculiar genetic loci, which provide acquired immunity against viruses and plasmids by targeting nucleic acid in a sequence-specific manner. These hypervariable l...
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تاریخ انتشار 2007